Freitas et al. BMC Infectious Diseases, : biomedcentral.comRESEARCH ARTICLEOpen AccessLipodystrophy
Ober
Freitas et al. BMC Infectious Ailments, : biomedcentral.comRESEARCH ARTICLEOpen AccessLipodystrophy defined by Fat Mass Ratio in HIVinfected patients is linked using a high prevalence of glucose disturbances 
and insulin resistancePaula Freitas, Davide Carvalho, A Cristi Santos, Joa Mesquita, Maria Jo Matos, Antonio Jose Madureira, Esteban Martinez, Ant io Sarmento and JosLu MediAbstractIntroduction: Combined antiretroviral therapy (cART) PubMed ID:http://jpet.aspetjournals.org/content/171/1/98 inside the treatment of HIV infection has been linked with complications, such as lipodystrophy, hyperlipidaemia, insulin resistance (IR) and diabetes. Aims: To compare the prevalence of glucose homeostasis disturbances and IR in HIV sufferers on cART according to the presence of lipodystrophy (defined clinically and by Fat Mass Ratio) and diverse patterns of fat 
distribution and to establish their associations. Style: Crosssectiol cohort study. Strategies: We evaluated physique composition and IR and insulin sensitivity indexes in HIVinfected adults. Benefits: Patients with clinical lipodystrophy (CL) had greater plasma glucose levels than individuals with no CL, without important differences in plasma insulin levels, Ac, HOMAIR, HOMAB, QUICKI, or MATSUDA index. Individuals with lipodystrophy defined by FMR had higher plasma glucose and insulin levels, Ac, HOMAIR, QUICKI and MATSUDA than individuals with no lipodystrophy, devoid of variations in HOMAB. Higher insulin resistance (HOMAIR ) was present in individuals with FMRdefined lipodystrophy. Individuals with FMRdefined lipodystrophy had a greater prevalence of IFG, IGT and DM than individuals without the need of lipodystrophy. Significant associations between HOMAIR and total, central and centralperipheral fat evaluated by CT at abdomil level have been located and no association involving HOMAIR and peripheral fat. Association in between HOMAIR and total and trunk fat but no association with leg and arm fat (evaluated by DXA) was discovered. Conclusions: IR and glucose disturbances had been significantly improved in patients with FMRdefined lipodystrophy. FMR lipodystrophy definition appears to become a much more sensitive determint of insulin resistance and glucose disturbances than clinical definition. Key phrases: Lipodystrophy, Insulin resistance, HIV, Glucose homeostasis disturbances Correspondence: [email protected] Division of Endocrinology, Hospital de S Jo, University of Porto Medical School, Alameda Hern i Monteiro,, Porto Portugal, Portugal Complete list of author details is available at the finish of your write-up Freitas et al.; licensee BioMed Central Ltd. This can be an Open Access short article distributed below the terms with the F16 Creative Commons Attribution License (http:creativecommons.orglicensesby.), which permits unrestricted use, distribution, and reproduction in any medium, offered the origil work is appropriately cited.Freitas et al. BMC Infectious Diseases, : biomedcentral.M1 receptor modulator comPage ofIntroduction Combined antiretroviral therapy (cART) within the treatment of HIV infection confers considerable survival benefit and has altered the tural history of this illness. Nonetheless, cART has been connected with metabolic complications, which includes hyperlipidemia, insulin resistance (IR), diabetes mellitus (DM) and lipodystrophy, with resultant improved threat of cardiovascular disease. DM can be a recognized complication of various antiretroviral therapies, getting related with both quick and longterm exposure to a few of these drugs. The reported prevalence of DM in HIVinfected populations ranges from to, with differences in preva.Freitas et al. BMC Infectious Illnesses, : biomedcentral.comRESEARCH ARTICLEOpen AccessLipodystrophy
Ober
Freitas et al. BMC Infectious Diseases, : biomedcentral.comRESEARCH ARTICLEOpen AccessLipodystrophy defined by Fat Mass Ratio in HIVinfected patients is linked using a high prevalence of glucose disturbances and insulin resistancePaula Freitas, Davide Carvalho, A Cristi Santos, Joa Mesquita, Maria Jo Matos, Antonio Jose Madureira, Esteban Martinez, Ant io Sarmento and JosLu MediAbstractIntroduction: Combined antiretroviral therapy (cART) PubMed ID:http://jpet.aspetjournals.org/content/171/1/98 inside the treatment of HIV infection has been connected with complications, including lipodystrophy, hyperlipidaemia, insulin resistance (IR) and diabetes. Aims: To evaluate the prevalence of glucose homeostasis disturbances and IR in HIV sufferers on cART in accordance with the presence of lipodystrophy (defined clinically and by Fat Mass Ratio) and distinct patterns of fat distribution and to establish their associations. Design: Crosssectiol cohort study. Procedures: We evaluated physique composition and IR and insulin sensitivity indexes in HIVinfected adults. Results: Sufferers with clinical lipodystrophy (CL) had larger plasma glucose levels than patients without the need of CL, with out considerable variations in plasma insulin levels, Ac, HOMAIR, HOMAB, QUICKI, or MATSUDA index. Sufferers with lipodystrophy defined by FMR had higher plasma glucose and insulin levels, Ac, HOMAIR, QUICKI and MATSUDA than patients with no lipodystrophy, with out variations in HOMAB. Higher insulin resistance (HOMAIR ) was present in sufferers with FMRdefined lipodystrophy. Sufferers with FMRdefined lipodystrophy had a higher prevalence of IFG, IGT and DM than individuals with out lipodystrophy. Important associations amongst HOMAIR and total, central and centralperipheral fat evaluated by CT at abdomil level have been identified and no association involving HOMAIR and peripheral fat. Association among HOMAIR and total and trunk fat but no association with leg and arm fat (evaluated by DXA) was discovered. Conclusions: IR and glucose disturbances had been significantly improved in individuals with FMRdefined lipodystrophy. FMR lipodystrophy definition appears to become a additional sensitive determint of insulin resistance and glucose disturbances than clinical definition. Search phrases: Lipodystrophy, Insulin resistance, HIV, Glucose homeostasis disturbances Correspondence: [email protected] Department of Endocrinology, Hospital de S Jo, University of Porto Healthcare School, Alameda Hern i Monteiro,, Porto Portugal, Portugal Complete list of author information and facts is offered at the finish on the short article Freitas et al.; licensee BioMed Central Ltd. This is an Open Access report distributed beneath the terms on the Creative Commons Attribution License (http:creativecommons.orglicensesby.), which permits unrestricted use, distribution, and reproduction in any medium, offered the origil work is effectively cited.Freitas et al. BMC Infectious Ailments, : biomedcentral.comPage ofIntroduction Combined antiretroviral therapy (cART) within the remedy of HIV infection confers substantial survival advantage and has altered the tural history of this disease. On the other hand, cART has been linked with metabolic complications, which includes hyperlipidemia, insulin resistance (IR), diabetes mellitus (DM) and lipodystrophy, with resultant enhanced threat of cardiovascular disease. DM is often a known complication of numerous antiretroviral therapies, being connected with each quick and longterm exposure to some of these drugs. The reported prevalence of DM in HIVinfected populations ranges from to, with differences in preva.