N from the marine diatom Odontella aurita Authors Year Journal Biochemical and Biophysical Analysis Communications Marine Drugs Bioscience, Biotechnology and Biochemistry Journal of Agricultural and Meals Chemistry Biochimica et Biophysica Acta (BBA)–General Subjects Journal of Agricultural and Food Chemistry Applied Biochemistry and Biotechnology Food and Chemical Toxicology European Journal of Pharmacology Marine Drugs Total CitationMaeda et al.Peng et al. Yan et al. Sachindra et al. Hosokawa et al.2011 1999 2007356 348 308Maeda et al. Kim et al. Heo et al.2007 2012226 218Kim et al. Xia et al.20102046. Investigation Ideas The keyword co-occurrence evaluation delivers an overview of fucoxanthin research ideas. Keyword phrases serve because the basic of bibliographic study of academic literature [45]. A total of 40 relevant key phrases have been classified into 4 distinct clusters applying a minimum occurrence of your 15-fold keyword (Ionomycin web Figure 4). The initial cluster (in red) consists of 18 keywords and phrases that revolved about “antioxidant activity”, “neuroprotection”, and “Rapacuronium bromide site cancer inhibition”. This cluster highlighted the bioactivities of fucoxanthin through in vitro study and in vivo study. Ten search phrases for instance “photosynthesis”, “photosystem”, “chlorophyllbinding proteins”, and “energy transfer” were noticed within the second cluster (in green). This cluster represents the research of photosynthesis that involved fucoxanthin. The third cluster (in blue) encompassed “chemistry”, “biosynthesis”, “extraction”, “purification”, and “biotechnology” key phrases. Therefore, this cluster depicted the optimization of processes in acquiring fucoxanthin as precious compounds. The fourth cluster (in yellow) revolved about the key keywords including “phytoplankton”, “community structure”, “pigment”, and “environmental monitoring”, which denoted the role of fucoxanthin inside the environmental study of phytoplankton.Mar. Drugs 2021, 19,ten ofFigure four. Visualization of keyword co-occurrence network evaluation (minimum occurrences: 15).six.1. Analysis Trends of Fucoxanthin Investigation from 1928 to June 2021 The 4 clusters (bioactivities, photosynthesis, optimization of method, atmosphere) were utilized to analyze the fucoxanthin study trends from 1928 to June 2021. Inside the initially period (1928970), the researchers focused on the optimization of approach cluster (88.88) (Figure 5). An equal percentage of fucoxanthin articles (five.56) was observed in photosynthesis and environment clusters, respectively. No bioactivities of fucoxanthin publication had been produced. Within the second period (1971980), the percentage of articles inside the optimization of approach cluster decreased by 22.92 when compared with the earlier period. Both photosynthesis and atmosphere clusters demonstrated the exact same percentage of publications, 17.02 (increased by 11.46). The bioactivities cluster remained 0 . There was a further reduction (2.95) of publications within the optimization of course of action cluster inside the third period (1981990) compared to the previous period. Within the identical period, the bioactivities, photosynthesis, and environment clusters increased the percentage of publications, 1.37, two.16, and 1.42 , respectively. Inside the fourth period (1991000), bioactivities and environment clusters skilled an increase of publications percentage, four.26, and 12.66 , respectively, in comparison with the preceding period. Alternatively, the optimization of course of action and photosynthesis clusters exhibited a fall of publications percentage, four.13, and 12.69 , respecti.