Product Name :
2-Iminobiotin hydrobromide
Description:
2-Iminobiotin hydrobromide (Guanidinobiotin hydrobromide) is a biotin (vitamin H or B7) analog. 2-Iminobiotin hydrobromide is a reversible nitric oxide synthases inhibitor with Kis of 21.8 and 37.5 μM for murine iNOS and rat n-cNOS, respectively. 2-Iminobiotin hydrobromide superimposes on hypothermia protects human neuronal cells from hypoxia-induced cell damage.
CAS:
76985-52-9
Molecular Weight:
324.24
Formula:
C10H18BrN3O2S
Chemical Name:
5-[(3aS,4S,6aR)-2-amino-1H,3aH,4H,6H,6aH-thieno[3,4-d]imidazol-4-yl]pentanoic acid hydrobromide
Smiles :
Br.NC1N[C@H]2CS[C@@H](CCCCC(O)=O)[C@H]2N=1
InChiKey:
JKIJLCYOCQWMQL-UFLZEWODSA-N
InChi :
InChI=1S/C10H17N3O2S.BrH/c11-10-12-6-5-16-7(9(6)13-10)3-1-2-4-8(14)15;/h6-7,9H,1-5H2,(H,14,15)(H3,11,12,13);1H/t6-,7-,9-;/m0./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
2-Iminobiotin hydrobromide (Guanidinobiotin hydrobromide) is a biotin (vitamin H or B7) analog. 2-Iminobiotin hydrobromide is a reversible nitric oxide synthases inhibitor with Kis of 21.8 and 37.5 μM for murine iNOS and rat n-cNOS, respectively. 2-Iminobiotin hydrobromide superimposes on hypothermia protects human neuronal cells from hypoxia-induced cell damage.|Product information|CAS Number: 76985-52-9|Molecular Weight: 324.{{Glasdegib} web|{Glasdegib} Smo|{Glasdegib} Protocol|{Glasdegib} In stock|{Glasdegib} supplier|{Glasdegib} Autophagy} 24|Formula: C10H18BrN3O2S|Chemical Name: 5-[(3aS,4S,6aR)-2-amino-1H,3aH,4H,6H,6aH-thieno[3,4-d]imidazol-4-yl]pentanoic acid hydrobromide|Smiles: Br.{{Deferoxamine} MedChemExpress|{Deferoxamine} Metabolic Enzyme/Protease|{Deferoxamine} Biological Activity|{Deferoxamine} Data Sheet|{Deferoxamine} manufacturer|{Deferoxamine} Autophagy} NC1N[C@H]2CS[C@@H](CCCCC(O)=O)[C@H]2N=1|InChiKey: JKIJLCYOCQWMQL-UFLZEWODSA-N|InChi: InChI=1S/C10H17N3O2S.PMID:24507727 BrH/c11-10-12-6-5-16-7(9(6)13-10)3-1-2-4-8(14)15;/h6-7,9H,1-5H2,(H,14,15)(H3,11,12,13);1H/t6-,7-,9-;/m0./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 125 mg/mL (385.52 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Application of low concentrations of 2-Iminobiotin (2-IB; 10 ng/mL and 30 ng/mL) superimposed on hypothermia abrogates the hypoxia-induced lactate dehydrogenase (LDH) increase, resulting in LDH levels that were not different from the normoxia control.|Products are for research use only. Not for human use.|