Product Name :
LDC7559
Description:
LDC7559 is a gasdermin D (GSDMD) inhibitor via blocking neutrophil extracellular trap (NET) in the late stages .
CAS:
2407782-01-6
Molecular Weight:
349.38
Formula:
C20H19N3O3
Chemical Name:
N-[5-(2-methoxyphenyl)-9-oxa-3,4-diazatricyclo[8.4.0.0³,⁷]tetradeca-1(10),4,6,11,13-pentaen-12-yl]acetamide
Smiles :
CC(=O)NC1=CC2OCC3=CC(=NN3CC=2C=C1)C1=CC=CC=C1OC
InChiKey:
IFOIINXSFCQLOV-UHFFFAOYSA-N
InChi :
InChI=1S/C20H19N3O3/c1-13(24)21-15-8-7-14-11-23-16(12-26-20(14)9-15)10-18(22-23)17-5-3-4-6-19(17)25-2/h3-10H,11-12H2,1-2H3,(H,21,24)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
LDC7559 is a gasdermin D (GSDMD) inhibitor via blocking neutrophil extracellular trap (NET) in the late stages .|Product information|CAS Number: 2407782-01-6|Molecular Weight: 349.38|Formula: C20H19N3O3|Chemical Name: N-[5-(2-methoxyphenyl)-9-oxa-3,4-diazatricyclo[8.{{Tedizolid} site|{Tedizolid} Anti-infection|{Tedizolid} Purity & Documentation|{Tedizolid} Data Sheet|{Tedizolid} custom synthesis|{Tedizolid} Autophagy} 4.0.0³,⁷]tetradeca-1(10),4,6,11,13-pentaen-12-yl]acetamide|Smiles: CC(=O)NC1=CC2OCC3=CC(=NN3CC=2C=C1)C1=CC=CC=C1OC|InChiKey: IFOIINXSFCQLOV-UHFFFAOYSA-N|InChi: InChI=1S/C20H19N3O3/c1-13(24)21-15-8-7-14-11-23-16(12-26-20(14)9-15)10-18(22-23)17-5-3-4-6-19(17)25-2/h3-10H,11-12H2,1-2H3,(H,21,24)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 125 mg/mL (357.{{Tacrine} MedChemExpress|{Tacrine} Cholinesterase (ChE)|{Tacrine} Purity & Documentation|{Tacrine} Data Sheet|{Tacrine} manufacturer|{Tacrine} Autophagy} 78 mM).PMID:23833812 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|LDC7559 (1 and 5 μM) inhibits IL-1β release upon inflammasome activation, and significantly blocks the lethal effect of both human and murine GSDMD NT domains transfected into HEK293T cells. LDC7559 functions directly through blocking the activity of the GSDMD NT domain, rather than interfering with the activation and cleavage process.|Products are for research use only. Not for human use.|