Product Name :
Remodelin — Acetyl-transferase NAT10 Inhibitor
Description:
Remodelin is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10. It can improve nuclear architecture, chromatin organization, and fitness of both human lamin A/C-depleted cells and HGPS-derived patient cells, and decrease markers of DNA damage in these cells. Using a combination of chemical, cellular, and genetic approaches, acetyl-transferase protein NAT10 was identified as the target of Remodelin that mediated nuclear shape rescue in laminopathic cells via microtubule reorganization. Down-regulation and mutations of the nuclear-architecture proteins lamin A and C cause misshapen nuclei and altered chromatin organization associated with cancer and laminopathies, including the premature-aging disease Hutchinson-Gilford progeria syndrome (HGPS). Remodelin is a useful chemical tool to study how NAT10 affects nuclear architecture and suggest alternative strategies for treating laminopathies and aging.
CAS:
949912-58-7
Molecular Weight:
282.36
Formula:
C15H14N4S
Chemical Name:
4-(2-(2-cyclopentylidenehydrazinyl)thiazol-4-yl)benzonitrile
Smiles :
N#CC1=CC=C(C=C1)C1=CSC(NN=C2CCCC2)=N1
InChiKey:
XAEJIFARBQJLML-UHFFFAOYSA-N
InChi :
InChI=1S/C15H14N4S/c16-9-11-5-7-12(8-6-11)14-10-20-15(17-14)19-18-13-3-1-2-4-13/h5-8,10H,1-4H2,(H,17,19)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Remodelin is a novel potent and selective inhibitor of the acetyl-transferase protein NAT10. It can improve nuclear architecture, chromatin organization, and fitness of both human lamin A/C-depleted cells and HGPS-derived patient cells, and decrease markers of DNA damage in these cells. Using a combination of chemical, cellular, and genetic approaches, acetyl-transferase protein NAT10 was identified as the target of Remodelin that mediated nuclear shape rescue in laminopathic cells via microtubule reorganization. Down-regulation and mutations of the nuclear-architecture proteins lamin A and C cause misshapen nuclei and altered chromatin organization associated with cancer and laminopathies, including the premature-aging disease Hutchinson-Gilford progeria syndrome (HGPS). Remodelin is a useful chemical tool to study how NAT10 affects nuclear architecture and suggest alternative strategies for treating laminopathies and aging.|Product information|CAS Number: 949912-58-7|Molecular Weight: 282.36|Formula: C15H14N4S|Chemical Name: 4-(2-(2-cyclopentylidenehydrazinyl)thiazol-4-yl)benzonitrile|Smiles: N#CC1=CC=C(C=C1)C1=CSC(NN=C2CCCC2)=N1|InChiKey: XAEJIFARBQJLML-UHFFFAOYSA-N|InChi: InChI=1S/C15H14N4S/c16-9-11-5-7-12(8-6-11)14-10-20-15(17-14)19-18-13-3-1-2-4-13/h5-8,10H,1-4H2,(H,17,19)|Technical Data|Appearance: Solid Power.{{HPPE} web|{HPPE} Metabolic Enzyme/Protease|{HPPE} Activator|{HPPE} Technical Information|{HPPE} Description|{HPPE} supplier} |Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO up to 100 mM|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{7-Amino-4-methylcoumarin} medchemexpress|{7-Amino-4-methylcoumarin} Anti-infection|{7-Amino-4-methylcoumarin} Purity & Documentation|{7-Amino-4-methylcoumarin} References|{7-Amino-4-methylcoumarin} manufacturer|{7-Amino-4-methylcoumarin} Epigenetics} |Shelf Life: ≥12 months if stored properly.PMID:25269910 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|How to use|In Vitro:|Remodelin was used at 1-10 µM in vitro and cellular assays.|In Vivo:|n/a|References:|Larrieu D, et al. Chemical inhibition of NAT10 corrects defects of laminopathic cells. (2014) Science 344(6183):527-32.Products are for research use only. Not for human use.|Documents||