Product Name :
(S)-Mapracorat
Description:
(S)-Mapracorat is a selective and less active glucocorticoid receptor agonist.
CAS:
887375-15-7
Molecular Weight:
462.48
Formula:
C25H26F4N2O2
Chemical Name:
(2S)-4-(5-fluoro-2,3-dihydro-1-benzofuran-7-yl)-4-methyl-1-[(2-methylquinolin-5-yl)amino]-2-(trifluoromethyl)pentan-2-ol
Smiles :
CC(C)(C[C@](O)(CNC1C=CC=C2N=C(C)C=CC=12)C(F)(F)F)C1C=C(F)C=C2CCOC2=1
InChiKey:
VJGFOYBQOIPQFY-DEOSSOPVSA-N
InChi :
InChI=1S/C25H26F4N2O2/c1-15-7-8-18-20(5-4-6-21(18)31-15)30-14-24(32,25(27,28)29)13-23(2,3)19-12-17(26)11-16-9-10-33-22(16)19/h4-8,11-12,30,32H,9-10,13-14H2,1-3H3/t24-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{MS170} web|{MS170} PROTAC|{MS170} Technical Information|{MS170} Description|{MS170} manufacturer|{MS170} Epigenetic Reader Domain}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
(S)-Mapracorat is a selective and less active glucocorticoid receptor agonist.|Product information|CAS Number: 887375-15-7|Molecular Weight: 462.48|Formula: C25H26F4N2O2|Chemical Name: (2S)-4-(5-fluoro-2,3-dihydro-1-benzofuran-7-yl)-4-methyl-1-[(2-methylquinolin-5-yl)amino]-2-(trifluoromethyl)pentan-2-ol|Smiles: CC(C)(C[C@](O)(CNC1C=CC=C2N=C(C)C=CC=12)C(F)(F)F)C1C=C(F)C=C2CCOC2=1|InChiKey: VJGFOYBQOIPQFY-DEOSSOPVSA-N|InChi: InChI=1S/C25H26F4N2O2/c1-15-7-8-18-20(5-4-6-21(18)31-15)30-14-24(32,25(27,28)29)13-23(2,3)19-12-17(26)11-16-9-10-33-22(16)19/h4-8,11-12,30,32H,9-10,13-14H2,1-3H3/t24-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 50.6 mg/mL (109.41 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Dantrolene} web|{Dantrolene} Neuronal Signaling|{Dantrolene} Purity & Documentation|{Dantrolene} Purity|{Dantrolene} custom synthesis|{Dantrolene} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:23937941 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|(S)-Mapracorat concentration dependently inhibited TNFα secretion from activated canine PBMC with IC50 value of approximately 0.2 nM.|In Vivo:|Intradermal injection of compound 48/80 (50 μg in 50 μL saline) resulted in a clear wheal and flare reaction over the 60 min observation period. Topical pre-treatment with (S)-Mapracorat (0.1%) leads to significant reduction in the wheal and flare responses compared to vehicle (acetone) treated areas.|Products are for research use only. Not for human use.|