Product Name :
Belizatinib
Description:
Belizatinib is an oral, dual, potent inhibitor of ALK and TRKA, TRKB, and TRKC, with IC50 of 0.7 nM for wild-type recombinant ALK kinase.
CAS:
1357920-84-3
Molecular Weight:
577.73
Formula:
C33H44FN5O3
Chemical Name:
4-fluoro-N-(6-{[4-(2-hydroxypropan-2-yl)piperidin-1-yl]methyl}-1-[(1s,4s)-4-[(propan-2-yl)carbamoyl]cyclohexyl]-1H-1,3-benzodiazol-2-yl)benzamide
Smiles :
CC(C)NC(=O)[C@@H]1CC[C@@H](CC1)N1C(NC(=O)C2C=CC(F)=CC=2)=NC2=CC=C(CN3CCC(CC3)C(C)(C)O)C=C12
InChiKey:
WSTUJEXAPHIEIM-FEGDYQJNSA-N
InChi :
InChI=1S/C33H44FN5O3/c1-21(2)35-30(40)24-8-12-27(13-9-24)39-29-19-22(20-38-17-15-25(16-18-38)33(3,4)42)5-14-28(29)36-32(39)37-31(41)23-6-10-26(34)11-7-23/h5-7,10-11,14,19,21,24-25,27,42H,8-9,12-13,15-18,20H2,1-4H3,(H,35,40)(H,36,37,41)/t24-,27+
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Belizatinib is an oral, dual, potent inhibitor of ALK and TRKA, TRKB, and TRKC, with IC50 of 0.7 nM for wild-type recombinant ALK kinase.|Product information|CAS Number: 1357920-84-3|Molecular Weight: 577.73|Formula: C33H44FN5O3|Chemical Name: 4-fluoro-N-(6-{[4-(2-hydroxypropan-2-yl)piperidin-1-yl]methyl}-1-[(1s,4s)-4-[(propan-2-yl)carbamoyl]cyclohexyl]-1H-1,3-benzodiazol-2-yl)benzamide|Smiles: CC(C)NC(=O)[C@@H]1CC[C@@H](CC1)N1C(NC(=O)C2C=CC(F)=CC=2)=NC2=CC=C(CN3CCC(CC3)C(C)(C)O)C=C12|InChiKey: WSTUJEXAPHIEIM-FEGDYQJNSA-N|InChi: InChI=1S/C33H44FN5O3/c1-21(2)35-30(40)24-8-12-27(13-9-24)39-29-19-22(20-38-17-15-25(16-18-38)33(3,4)42)5-14-28(29)36-32(39)37-31(41)23-6-10-26(34)11-7-23/h5-7,10-11,14,19,21,24-25,27,42H,8-9,12-13,15-18,20H2,1-4H3,(H,35,40)(H,36,37,41)/t24-,27+|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 300 mg/mL (519.{{Diacerein} MedChemExpress|{Diacerein} Interleukin Related|{Diacerein} Biological Activity|{Diacerein} In stock|{Diacerein} supplier|{Diacerein} Epigenetics} 27 mM).{{Cemiplimab} site|{Cemiplimab} PD-1/PD-L1|{Cemiplimab} Technical Information|{Cemiplimab} Description|{Cemiplimab} supplier|{Cemiplimab} Epigenetics} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:31085260 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|TSR-011 has antitumour activity in the clinical trials.|In Vivo:|TSR-011 exerts sustained potent inhibition of ALK-dependent tumour growth in mouse models.|Products are for research use only. Not for human use.|