Product Name :
AX-024 HCl
Description:
AX-024 is an orally available inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation (IC50 value 1 nM). Inhibiting an immediate TCR signal has promise for treating a broad spectrum of human T cell-mediated autoimmune and inflammatory diseases.
CAS:
1704801-24-0
Molecular Weight:
375.86
Formula:
C21H23ClFNO2
Chemical Name:
1-((4-(4-Fluorophenyl)-6-methoxy-2H-chromen-3-yl)methyl)pyrrolidine hydrochloride
Smiles :
Cl.COC1=CC2=C(C=C1)OCC(CN1CCCC1)=C2C1C=CC(F)=CC=1
InChiKey:
DGBCIMPGYRVTPD-UHFFFAOYSA-N
InChi :
InChI=1S/C21H22FNO2.ClH/c1-24-18-8-9-20-19(12-18)21(15-4-6-17(22)7-5-15)16(14-25-20)13-23-10-2-3-11-23;/h4-9,12H,2-3,10-11,13-14H2,1H3;1H
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
AX-024 is an orally available inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation (IC50 value 1 nM). Inhibiting an immediate TCR signal has promise for treating a broad spectrum of human T cell-mediated autoimmune and inflammatory diseases.|Product information|CAS Number: 1704801-24-0|Molecular Weight: 375.86|Formula: C21H23ClFNO2|Chemical Name: 1-((4-(4-Fluorophenyl)-6-methoxy-2H-chromen-3-yl)methyl)pyrrolidine hydrochloride|Smiles: Cl.COC1=CC2=C(C=C1)OCC(CN1CCCC1)=C2C1C=CC(F)=CC=1|InChiKey: DGBCIMPGYRVTPD-UHFFFAOYSA-N|InChi: InChI=1S/C21H22FNO2.ClH/c1-24-18-8-9-20-19(12-18)21(15-4-6-17(22)7-5-15)16(14-25-20)13-23-10-2-3-11-23;/h4-9,12H,2-3,10-11,13-14H2,1H3;1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO: 75 mg/mL(199.{{FIPI} MedChemExpress|{FIPI} Autophagy|{FIPI} Purity & Documentation|{FIPI} In Vitro|{FIPI} manufacturer|{FIPI} Autophagy} 54 mM).{{Matuzumab} MedChemExpress|{Matuzumab} Protein Tyrosine Kinase/RTK|{Matuzumab} TGF-beta/Smad|{Matuzumab} Protocol|{Matuzumab} References|{Matuzumab} supplier} Water: 4 mg/mL(10.PMID:35954127 64 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Borroto A, et al. First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases. Sci Transl Med. 2016 Dec 21;8(370):370ra184.Products are for research use only. Not for human use.|