Product: Dorzolamide (hydrochloride)
mGluR1 Antibody Summary
| Immunogen |
Synthetic 16 amino acid peptide from C-terminus of human GRM1 / MGLUR1.
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| Specificity |
Human GRM1 / MGLUR1, isoform alpha. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
GRM1
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| Purity |
Immunogen affinity purified
|
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Applications/Dilutions
| Dilutions |
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Reactivity Notes
Chimpanzee, Gorilla, Gibbon, Marmoset. Predicted cross-reactivity based on sequence identity: Rabbit (81%).
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
0.1% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for mGluR1 Antibody
- glutamate receptor, metabotropic 1
- GPRC1A
- GRM1
- GRM1A
- metabotropic glutamate receptor 1
- mGluR1
- MGLUR1A
- MGLUR1GPRC1AmGlu1
Background
The Metabotropic Glutamate Receptor mGluR1 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. mGluR1 and mGluR5 are group I receptors that have been shown to activate phospholipase C. Alternative splice variants of the mGluR1 gene have been described, but their full-length nature has not been determined. Inflammation results in the activation of mGluR1 and mGluR5 in dorsal horn neurons of the spinal cord, leading to extracellular signalregulated kinase (ERK) activation, which is required for nociceptive plasticity and enhanced pain.