Pappalysin-1/PAPP-A Antibody Summary
| Immunogen |
This antibody is specific for the Middle Region of the target protein.
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| Specificity |
This product is specific for Human PAPPA.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
PAPPA
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
This antibody is useful in ELISA and Western Blot.
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| Publications |
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Reactivity Notes
Human.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
20mM Potassium Phosphate (pH 7.0) and 0.15M NaCl
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| Preservative |
No Preservative
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| Purity |
Immunogen affinity purified
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Notes
Manufactured by SDIXs proprietary Genomic Antibody Technology™. GAT FAQs.
Alternate Names for Pappalysin-1/PAPP-A Antibody
- ASBABP2
- DIPLA1
- EC 3.4.24.79
- IGFBP-4ase
- IGFBP-4aseaspecific BCL2 ARE-binding protein 2
- IGF-dependent IGFBP-4 protease
- insulin-like growth factor-dependent IGF binding protein-4 protease
- Insulin-like growth factor-dependent IGF-binding protein 4 protease
- PAPA
- PAPPA
- PAPPA1
- PAPP-A1
- PAPP-Adifferentially placenta 1 expressed protein
- Pappalysin1
- Pappalysin-1
- pregnacy-associated plasma protein A
- Pregnancy-associated plasma protein A
- pregnancy-associated plasma protein A, pappalysin 1
Background
PAPP A was originally isolated from pregnancy serum as heterotetrameric protein complex with molecular weight approximately 500 kDa, consisting of two PAPP A subunits disulfide-linked with two subunits of the proform of eosinophil major basic protein (proMBP). In such a complex proMBP functions as an inhibitor of PAPP A proteinase activity. PAPP A is widely used as a marker of some pathologies during pregnancy. Reduced level of PAPP A in pregnancy blood in the first trimester is associated with fetal Down syndrome. PAPP A is considered as one of the best biochemical markers in early pregnancy used to screen for Down syndrome during the first trimester (Wald, N. J. et al).