Neurotensin Receptor 1 Antibody Summary
| Immunogen |
Synthetic 18 amino acid peptide from N-terminal extracellular domain of human NTSR1.
|
| Epitope |
N-terminal extracellular domain of human
|
| Specificity |
Human NTSR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
|
| Predicted Species |
Primate (100%). Backed by our 100% Guarantee.
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
NTSR1
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Elephant (94%), Marmoset (89%), Hamster (83%).
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
0.1% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for Neurotensin Receptor 1 Antibody
- High-affinity levocabastine-insensitive neurotensin receptor
- neurotensin receptor 1 (high affinity)
- neurotensin receptor type 1
- NTR
- NTR1
- NT-R-1
- NTRH
- NTRR
Background
NTR1, a Neurotensin Receptor, activates a phosphatidylinositol-calcium second messenger system in the central and peripheral nervous systems. It mediates the functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. Neurotensin Receptor 1 expression is enhanced in pancreatic cancer and in chronic pancreatitis (Wang et al, 2000). Two differentially glycosylated forms of the NT1 receptor have been identified in rats, a 54-kDa form that is expressed from birth to adulthood, and a 52-kDa form only detected at 10 and 15 days postnatal. NTR1 has been reported in brain, pancreas, and small intestine. ESTs have been isolated from brain and colon libraries.