Product: Deoxycytidine triphosphate
PP2A alpha Antibody (P6C7) Summary
| Immunogen |
Recombinant human PP2Ckappa protein.
|
| Isotype |
IgG2b Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
PPP2CA
|
| Purity |
Protein G purified
|
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|
Applications/Dilutions
| Dilutions |
|
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
0.1% Sodium Azide
|
| Purity |
Protein G purified
|
Alternate Names for PP2A alpha Antibody (P6C7)
- EC 3.1.3.16
- PP2A
- PP2A-alpha
- PP2Ac
- PP2CA
- PP2Calpha
- PPP2CA
- protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
- protein phosphatase 2, catalytic subunit, alpha isozyme
- protein phosphatase 2A catalytic subunit, alpha isoform
- Replication protein C
- RP-C
- serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform
- serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Background
Protein phosphatase type 2A (PP2A) is a protein serine/threonine phosphatase that controls fundamental cellular processes, including transcription, translation, metabolism, cell growth, apoptosis, and varied other signal transduction pathways (1-3). PP2A is comprised of a core enzyme, which is made up of catalytic C and regulatory A (PR65) subunits, and a secondary regulatory B subunit. This B subunit contains four different protein families. In response to EGF or insulin, it has been shown that Src phosphorylates PP2A at Tyr307, thereby inactivating PP2A (4).