RAR beta/NR1B2 Antibody Summary
| Immunogen |
Synthetic 13 amino acid peptide from C-terminus of human RARB.
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| Epitope |
C-terminal region of human
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| Localization |
Cytoplasmic (isoform beta 4) and Nuclear (isoforms beta 1 and beta 2).
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| Specificity |
Human RARB. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
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| Predicted Species |
Canine (92%), Opossum (100%), Chicken (92%), Turkey (92%). Backed by our 100% Guarantee.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
RARB
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
IHC-F usage is reported in scientific literature (PMID: 21785820).
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| Publications |
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Reactivity Notes
Gorilla, Gibbon, Marmoset. Predicted cross-reactivity based on sequence identity: Mouse (85%), Panda (85%).
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
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| Preservative |
0.1% Sodium Azide
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| Concentration |
1.0 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for RAR beta/NR1B2 Antibody
- beta polypeptide
- HAP
- HBV-activated protein
- NR1B2
- RAR beta
- RARB
- retinoic acid receptor, beta
- RRB2
Background
Retinoic acid receptor beta (RAR beta), a NR1 Thyroid Hormone-Like Receptor, is involved in the regulation of cell growth, differentiation, apoptosis, and carcinogenesis. RAR beta forms heterodimers with the retinoic acid X receptor (RXR) and binds to the direct repeat 1 (DR1) sequence of target DNA. A growing body of evidence supports the hypothesis that RAR beta is a tumor-suppressor gene. Altered expression of RAR beta has been linked to cancers, including those of the head and neck, lung, esophagus, breast, pancreas, and cervix. Three isoforms of RAR beta, beta 1, beta 2, and beta 4, have been documented in humans.