Sphingosine Kinase 1/SPHK1 Antibody Summary
| Immunogen |
Synthetic 15 amino acid peptide from N-terminus of human SPHK1.
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| Epitope |
N-terminal domain of human
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| Localization |
Cytoplasmic
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| Specificity |
This is specific to the human Sphingosine Kinase Type 1 protein.
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| Predicted Species |
Primate (100%), Bat (100%), Canine (93%), Rabbit (100%). Backed by our 100% Guarantee.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
SPHK1
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| Purity |
Immunogen affinity purified
|
| Innovators Reward |
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Applications/Dilutions
| Dilutions |
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| Publications |
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Reactivity Notes
Gibbon (100%), Elephant, Panda (93%), Horse (87%); Mouse, Rat, Bovine (80%).
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
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| Preservative |
0.1% Sodium Azide
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| Concentration |
1.0 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for Sphingosine Kinase 1/SPHK1 Antibody
- EC 2.7.1.91
- SK1
- sphingosine kinase 1
- SPHK1
- SPHKSK 1
- SPK 1
- SPK
- SPK1
Background
Sphingosine kinase (SPHK) phosphorylates sphingosine to form a bioactive lipid mediate, sphingosine 1-phosphate (S1P or SPP). S1P is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival while extracellularly it is a ligand for EDG 1. Expression of SPHK1 and subsequent production of S1P promotes the G1-S transition, protects cells from apoptosis, stimulates migration and angiogenesis and induces tumor formation in mice.