UACA Antibody Summary
| Immunogen |
The immunogen recognized by this antibody maps to a region between residue 1075 and 1125 of human uveal autoantigen with coiled-coil domains and ankyrin repeats using the numbering given in entry NP_060473.2 (GeneID 55075).
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| Predicted Species |
Primate (100%), Ferret (100%), Bovine (100%), Squirrel (100%), Rabbit (100%). Backed by our 100% Guarantee.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
UACA
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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Reactivity Notes
Human. Based on 100% sequence identity, this antibody is predicted to react with Bovine, Rabbit, Panda, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear marmoset, European domestic ferret, Northern white-cheeked gibbon, and Thirteen-lined ground squirrel.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
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| Buffer |
TBS and 0.1% BSA
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| Preservative |
0.09% Sodium Azide
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| Concentration |
0.2 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for UACA Antibody
- FLJ10128
- KIAA1561MGC141969
- MGC141967
- nuclear membrane binding protein
- NUCLING
- uveal autoantigen with coiled coil domains and ankyrin repeats
- uveal autoantigen with coiled-coil domains and ankyrin repeats
Background
UACA (uveal autoantigen with coiled-coil domains and ankyrin repeats) was originally identified as an autoantigen in patients with panuveitis, a characteristic of Vogt-Koyanagi-Harada disease, and in patients with Graves disease. UACA was also later identified as Nucling, an mRNA differentially expressed in F9 embryonal carcinoma cells during cardiac muscle differentiation. UACA appears to function as a pro-apoptotic protein that recruits the apaf-1-pro-caspase-9 complex for the induction of apoptosis to mediate the cell-death pathway.