AlmiRNA(s)DovepressmiR1273p, miR-148b, miR376a, miR376c, miR4093p, miR652, miRsubmit your manuscript | www.dovepress.commiR133a, miR-148bmiRmiR-148b, miR376c, miR4093p, miRmiR-155, miRmiRmiRNotes: This is a representative sample of 20 current studies identified on a PubMed query (breast cancer blood miRNA miR) that describe individual miRNAs or miRNA signatures getting possible application for early illness detection. Research with fewer than 20 BC cases were excluded. While these signatures mainly reflect higher amounts of circulating miRNAs, some miRNAs are detected at decrease levels in blood samples of BC patients. Blood collection was performed before surgery unless otherwise indicated. miRNAs shown in bold indicate a recurrent presence in at the very least 3 independent research. Abbreviations: BC, breast cancer; DCiS, ductal carcinoma in situ; eR, estrogen receptor; LN, lymph node status; miRNA, microRNA; qRTPCR, quantitative realtime polymerase chain reaction.Breast Cancer: Targets and Therapy 2015:DovepressDovepressmicroRNAs in breast cancerTable 2 miRNArelated risk loci associated with BCGene locus MIR27A SNP rs895919 *C Comments Population Asians Caucasians Jewish BRCA2 carriers Caucasian Asians Caucasians Chinese (young) Chinese Asians Caucasians African Americans African Americans european Americans Chinese Chinese African Americans european Americans African Americans european Americans italian Caucasians Chinese Asians Caucasians Asians Asians Caucasians Chinese Asians Caucasians Chinese Asians Caucasians African Americans African Americans Korean italian and German Asians Caucasians Brazilian Caucasian Chinese and Korean Chinese Chinese African Americans european Americans Asians Caucasians African Americans european Americans African a0023781 Americans African Americans european Americans African Americans european Americans Asians Caucasians Clinical observation No threat HS-173 dose association Protective dar.12324 elevated risk Decreased danger No danger association Decreased risk Decreased risk Decreased danger No risk association No risk association elevated survival No danger association Decreased overall risk enhanced threat elevated danger No threat association elevated all round danger Decreased threat of eR+ BC No risk association earlier age of onset No danger association No risk association No risk association No risk association Decreased danger (C allele) No risk association No threat association No danger association No danger association No threat association No threat association No threat association No risk association Reduced threat Lowered threat Survival of HeR2+ instances No threat association Decreased danger No threat association Decreased danger Decreased danger Decreased threat increased threat improved danger No danger association No danger association No danger association No risk association Decreased risk of eR- BC No risk association enhanced survival elevated risk of eR- BC No danger association No danger association elevated overall threat No danger association No threat association Reference 141 142 143 144 35 34 31 145 33 38 38 33 33 146 147 83 38 144 31 36 38 36 31 145 145 148 37 141 149 147 32 36 83 33 31 33 145 33 33rs895819 A/GpremiRNA premiRNA premiRNA premiRNAMIR34B cluster MIR100 MIR101-2 MIR106B MIR122A MIR146Ars4938723 T/C rs1834306 G/A rs1053872 C/G rs462480 A/C rs1527423 A/G rs17669 A/G Mirogabalin web rs2910164 G/C Principal transcript Major transcriptMIRrs2292832 T/GMIR185 MIR196A-rs2008591 C/T rs887205 A/G rs11614913 T/CMIR204 MIR206 MIR219 MIR331 MIRrs7861254 G rs6920648 A/G rs107822 G/A rs.AlmiRNA(s)DovepressmiR1273p, miR-148b, miR376a, miR376c, miR4093p, miR652, miRsubmit your manuscript | www.dovepress.commiR133a, miR-148bmiRmiR-148b, miR376c, miR4093p, miRmiR-155, miRmiRmiRNotes: This can be a representative sample of 20 current studies found on a PubMed query (breast cancer blood miRNA miR) that describe person miRNAs or miRNA signatures possessing prospective application for early illness detection. Research with fewer than 20 BC situations had been excluded. Although these signatures primarily reflect higher amounts of circulating miRNAs, some miRNAs are detected at reduce levels in blood samples of BC individuals. Blood collection was performed just before surgery unless otherwise indicated. miRNAs shown in bold indicate a recurrent presence in at the least 3 independent research. Abbreviations: BC, breast cancer; DCiS, ductal carcinoma in situ; eR, estrogen receptor; LN, lymph node status; miRNA, microRNA; qRTPCR, quantitative realtime polymerase chain reaction.Breast Cancer: Targets and Therapy 2015:DovepressDovepressmicroRNAs in breast cancerTable 2 miRNArelated danger loci related to BCGene locus MIR27A SNP rs895919 *C Comments Population Asians Caucasians Jewish BRCA2 carriers Caucasian Asians Caucasians Chinese (young) Chinese Asians Caucasians African Americans African Americans european Americans Chinese Chinese African Americans european Americans African Americans european Americans italian Caucasians Chinese Asians Caucasians Asians Asians Caucasians Chinese Asians Caucasians Chinese Asians Caucasians African Americans African Americans Korean italian and German Asians Caucasians Brazilian Caucasian Chinese and Korean Chinese Chinese African Americans european Americans Asians Caucasians African Americans european Americans African a0023781 Americans African Americans european Americans African Americans european Americans Asians Caucasians Clinical observation No threat association Protective dar.12324 improved danger Decreased risk No danger association Decreased threat Decreased threat Decreased risk No danger association No threat association improved survival No risk association Decreased all round risk increased threat elevated threat No danger association improved overall danger Decreased threat of eR+ BC No danger association earlier age of onset No risk association No threat association No danger association No threat association Decreased risk (C allele) No risk association No risk association No risk association No danger association No threat association No risk association No risk association No risk association Lowered danger Reduced risk Survival of HeR2+ situations No risk association Decreased risk No danger association Decreased risk Decreased threat Decreased risk increased risk increased danger No threat association No threat association No danger association No threat association Decreased danger of eR- BC No threat association increased survival increased threat of eR- BC No danger association No threat association improved overall threat No threat association No danger association Reference 141 142 143 144 35 34 31 145 33 38 38 33 33 146 147 83 38 144 31 36 38 36 31 145 145 148 37 141 149 147 32 36 83 33 31 33 145 33 33rs895819 A/GpremiRNA premiRNA premiRNA premiRNAMIR34B cluster MIR100 MIR101-2 MIR106B MIR122A MIR146Ars4938723 T/C rs1834306 G/A rs1053872 C/G rs462480 A/C rs1527423 A/G rs17669 A/G rs2910164 G/C Key transcript Key transcriptMIRrs2292832 T/GMIR185 MIR196A-rs2008591 C/T rs887205 A/G rs11614913 T/CMIR204 MIR206 MIR219 MIR331 MIRrs7861254 G rs6920648 A/G rs107822 G/A rs.