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Assessment ARTICLEpublished: 14 January 2013 doi: 10.3389/fimmu.2012.The part of non-hematopoietic stromal cells in the persistence of inflammationFrancesca Barone, Saba Nayar and Chris D. BuckleyCentre for Translational Inflammation Research, Arthritis Study UK, Rheumatology Study Group, College of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham Investigation Laboratories, Queen Elizabeth Hospital, Birmingham, UK Edited by: Mark C. Coles, University of York, UK Reviewed by: Masaaki Murakami, Osaka University, Japan Nancy Ruddle, Yale University School of Medicine, USACorrespondence: Francesca Barone and Chris D. Buckley, Centre for Translational Inflammation Analysis, Arthritis Study UK, Rheumatology Study Group, College of Immunity and Infection, Keyword phrases: endothelium, lymphatics, rheumatoid arthritis, ectopic lymphoneogenesis, fibroblasts College of Health-related and Dental Sciences, University of Birmingham Study Laboratories, Queen Elizabeth Hospital, Birmingham B15 2WD, UK. e-mail: [email protected]; [email protected] results from the complex interaction in between hematopoietic and stromal cells and increasing proof supports a key function for the stroma in driving the switch from acute resolving to persistence in chronic inflammatory diseases. Stromal cells have also been shown to play a important role in cancer biology, being involved in cancer growth, dissemination, and SC-58125 Technical Information inhibition of the autologous immune response, in the end favoring persistence and metastatic spread. Similarly, blood and lymphatic endothelial cells contribute to tissue homeostasis during physiological inflammation but in addition result in discorded leukocyte and tumor cell accumulation in pathological inflammation and cancer. This evaluation aims to summarize the role that pathogenic stroma.