[email protected] (M.M.P.); [email protected] (O.A.G.) Department of Physiotherapy, Faculty of Continuing Healthcare Education, Peoples’ Friendship University of Russia, 117198 Moscow, Russia; [email protected] Department of Neurology and Neurosurgery, Siberian State Health-related University, 634050 Tomsk, Russia; [email protected] Correspondence: [email protected] (R.F.N.); [email protected] (N.A.S.); Tel.: 7-(812)-670-02-20 (R.F.N. N.A.S.)Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.Abstract: Amyotrophic lateral sclerosis (ALS) is an incurable chronic progressive neurodegenerative disease with the progressive degeneration of motor neurons within the motor cortex and reduce motor neurons in the spinal cord as well as the brain stem. The etiology and pathogenesis of ALS are getting actively studied, but there’s nonetheless no single concept. The study of ALS threat aspects can assist to understand the mechanism of this disease improvement and, possibly, slow down the rate of its progression in patients and also lessen the danger of its development in individuals having a predisposition toward familial ALS. The interest of researchers and clinicians within the protective part of nutrients within the improvement of ALS has been rising in current years. However, the role of a few of them will not be well-understood or disputed. The objective of this critique is to analyze studies on the part of nutrients as environmental Goralatide Description factors affecting the danger of building ALS and the rate of motor neuron degeneration progression. Procedures: We searched the PubMed, Springer, Clinical keys, Google Scholar, and E-Library databases for publications making use of keywords and Cholesteryl sulfate Epigenetic Reader Domain phrases and their combinations. We analyzed all of the offered research published in 2010020. Discussion: We analyzed 39 studies, including randomized clinical trials, clinical instances, and meta-analyses, involving ALS sufferers and studies on animal models of ALS. This review demonstrated that the following vitamins would be the most considerable protectors of ALS improvement: vitamin B12, vitamin E vitamin C vitamin B1, vitamin B9 vitamin D vitamin B2, vitamin B6 vitamin A, and vitamin B7. Furthermore, this critique indicates that the role of foods with a higher content of cholesterol, polyunsaturated fatty acids, urates, and purines plays a huge aspect in ALS development. Conclusion: The inclusion of vitamins plus a ketogenic diet regime in disease-modifying ALS therapy can cut down the progression rate of motor neuron degeneration and slow the price of disease progression, but the strategy to nutrient selection must be customized. The roles of vitamins C, D, and B7 as ALS protectors require additional study. Key phrases: amyotrophic lateral sclerosis; predictor; danger issue; protector; nutrient; vitaminCopyright: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is definitely an open access write-up distributed beneath the terms and situations from the Inventive Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).1. Introduction Amyotrophic lateral sclerosis (ALS) is definitely an incurable chronic progressive neurodegenerative illness with the progressive degeneration of motor neurons within the motor cortex andNutrients 2021, 13, 3804. https://doi.org/10.3390/nuhttps://www.mdpi.com/journal/nutrientsNutrients 2021, 13,two oflower motor neurons in the spinal cord plus the brain stem [1]. As a rule, patients die from respiratory failure three years right after onset of the disease. The inci.