enes at this time happen to be connected with all the pathogen manipulation of your host, because the use of sugars like fructose and amino acids are essential sources to get a profitable colonization, as described in P. infestans (Botero et al., 2018). This also indicates that the interaction among S. betaceum and P. betacei is compatible, as the induction of expression of those genes correlates using a much more susceptible interaction (Duan et al., 2020). Of your functional category for secondary metabolite production, at 24 hpi there was an all round enrichment, in S1PR4 supplier specific of biosynthesis of terpenoid, phenylpropanoid, and lignin, generally active defense pathways against mGluR8 drug biotic and abiotic strain (Paolinelli-Alfonso et al., 2016). The synthesis of a secondary wall containing lignin helps within the reinforcement on the wall and hinders the entry of the pathogen (Miedes et al., 2014). Likewise, the activation of terpenoid and phenylpropanoid produces phytoalexins, which present antimicrobial properties and accumulate in dying cells (Bell et al., 1986). Nonetheless, the expression of phytoalexins in early infection is related to an incompatible interaction (host resistance) (Bell et al., 1986). At 72 hpi, we observed a clear response in the plant expression to the pathogen switch: genes associated to intracellular signaling and HR are activated. Noteworthy, ERF, putative late blight protein R1-A10 and R1B23, and senescence-specific cysteine protease SAG12 were expressed, suggesting an induced leaf senescence, triggered by the pathogen to complete the infection cycleFrontiers in Plant Science | frontiersin.orgOctober 2021 | Volume 12 | ArticleBautista et al.Solanum betaceum Response P. betacei(Noh and Amasino, 1999). As infection approached 96 hpi, genes connected to these terms continue their induction with addition to senescence related terms and jasmonic acid metabolic course of action. The jasmonate and ethylene signal pathways are commonly linked using the response to necrotrophic pathogens (Sun, 2017).AUTHOR CONTRIBUTIONSSR, AB, and NG-P planned and made the study. NG-P, DBa, and MCB performed the experiments. DBa, DBo, JD, AB, and SR analyzed the data. DBa, JD, MC, and SR wrote the manuscript. All authors contributed to the post and approved the submitted version.CONCLUSIONIn conclusion, we obtained the very first time-series transcriptome of S. betaceum using a comprehensive expression profile across infection caused by P. betacei. From these data, we observed a close interaction among the host transcriptional response plus the hemibiotrophic infection tactic in the pathogen, exhibiting a dynamic defense-related gene response throughout the course of infection. We observed different upregulated genes, related to susceptibility and resistance, that elucidate the continuous response within this compatible interaction: in the recognition on the pathogen and the activation of defense related pathways to the final stages of infection with the expression of genes associated with cell death. We hypothesized the nature of this interaction as ETS, using a reprogramming of your host transcription caused by the pathogen for crucial sources to help in its colonization. Further analysis with resistant cultivars can be valuable to understand the molecular mechanisms underlying resistance in tree tomato.FUNDINGThis operate was supported by the Division of Biological Sciences at Universidad de los Andes as well as the Research Fund of your School of Sciences and the Workplace of th