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(2022) 16:1 Ho et al. Human Genomics doi.org/10.1186/s40246-021-00374-GENE Family UPDATEOpen AccessUpdate from the keratin gene family: evolution, tissue-specific expression patterns, and relevance to clinical disordersMinh Ho1, Brian Thompson2, Jeffrey Nicholas Fisk3, Daniel W. Nebert4,5, Elspeth A. Bruford6,7, Vasilis Vasiliou2 and Christopher G. Bunick1,8Abstract Intermediate filament (IntFil) genes arose through early metazoan evolution, to supply mechanical help for plasma m