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Glutamate would be the most abundant neurotransmitter, mediating practically 80 of synaptic transmission within the brain (Benarroch, 2010). To manage the fast extracellular buildup and stop the dangerous consequences of overstimulating glutamate receptors, an effective transport technique dynamically regulates the extracellular glutamate levels, as a result preventing glutamate accumulation and “spillover” amongst neighboring synapses (Dunlop, 2006). The astroglial-specific glutamate transporter-I subtype (GLT-I) will be the dominant glutamate transporter in the adult brain. This transporter’s importance is underscored by the impact of.