Product Name :
Lodoxamide Tromethamine
Description:
Lodoxamide tromethamine is used as an ophthalmic solution that specially applying to the eye.
CAS:
63610-09-3
Molecular Weight:
276.95
Formula:
C19H28ClN5O12
Chemical Name:
2-Amino-2-(hydroxymethyl)propane-1,3-diol;2-[2-chloro-5-cyano-3-(oxaloamino)anilino]-2-oxoacetic acid
Smiles :
NC(CO)(CO)CO.NC(CO)(CO)CO.N#CC1=CC(NC(=O)C(O)=O)=C(Cl)C(=C1)NC(=O)C(O)=O
InChiKey:
JJOFNSLZHKIJEV-UHFFFAOYSA-N
InChi :
InChI=1S/C11H6ClN3O6.2C4H11NO3/c12-7-5(14-8(16)10(18)19)1-4(3-13)2-6(7)15-9(17)11(20)21;2*5-4(1-6,2-7)3-8/h1-2H,(H,14,16)(H,15,17)(H,18,19)(H,20,21);2*6-8H,1-3,5H2
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Lodoxamide tromethamine is used as an ophthalmic solution that specially applying to the eye.|Product information|CAS Number: 63610-09-3|Molecular Weight: 276.95|Formula: C19H28ClN5O12|Synonym:|U-42585E|Almide|Alomide|Lodoxamide trometamol|Lodoxamide tromethamine|Related CAS Number:|66771-98-0 (Deleted)|Chemical Name: 2-Amino-2-(hydroxymethyl)propane-1,3-diol;2-[2-chloro-5-cyano-3-(oxaloamino)anilino]-2-oxoacetic acid|Smiles: NC(CO)(CO)CO.NC(CO)(CO)CO.N#CC1=CC(NC(=O)C(O)=O)=C(Cl)C(=C1)NC(=O)C(O)=O|InChiKey: JJOFNSLZHKIJEV-UHFFFAOYSA-N|InChi: InChI=1S/C11H6ClN3O6.{{Decitabine} site|{Decitabine} Nucleoside Antimetabolite/Analog|{Decitabine} Purity & Documentation|{Decitabine} Data Sheet|{Decitabine} custom synthesis|{Decitabine} Epigenetics} 2C4H11NO3/c12-7-5(14-8(16)10(18)19)1-4(3-13)2-6(7)15-9(17)11(20)21;2*5-4(1-6,2-7)3-8/h1-2H,(H,14,16)(H,15,17)(H,18,19)(H,20,21);2*6-8H,1-3,5H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO: Insoluble. Water: 19 mg/mL(34.3 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Procarbazine} MedChemExpress|{Procarbazine} Cell Cycle/DNA Damage|{Procarbazine} Protocol|{Procarbazine} In Vitro|{Procarbazine} supplier|{Procarbazine} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:28739548 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|lodoxamide inhibits compound 48/80-induced histamine release and ionophore-induced 45Ca influx with associated histamine release in purified rat peritoneal mast cells[1].|In Vivo:|Lodoxamide has been demonstrated to have cromolyn-like activity when studied in the rat peritoneal mast cell assay (PCA) model3 and in Ascaris antigen-sensitized rhesus monkeys. When given intravenously, orally, or intrabronchially by aerosol, lodoxamide significantly inhibits the increased respiratory frequency and decreased tidal volume induced by antigen challenge in Ascaris-sensitized. anesthetized rhesus monkeys[1]. Addition of lodoxamide tromethamine to Euro-Collins or University of Wisconsin solution results in a marked decrease in lung reperfusion injury as demonstrated by increased oxygenation, decreased microvascular permeability, and increased compliance[2]. Patients treated with lodoxamide tromethamine demonstrate an improvement in daytime breathing difficulty, cough, sputum production, and sleep[3].|References:|Watt GD, et al. Protective effect opf lodoxamide tromethamine on allergen inhalation challenge. J Allergy Clin Immunol. 1980 Oct;66(4):286-94.Barr ML, et al. Addition of a mast cell stabilizing compound to organ preservation solutions decreases lung reperfusion injury. J Thorac Cardiovasc Surg. 1998 Mar;115(3):631-6; discussion 636-7.Mann JS, et al. Inhaled lodoxamide tromethamine in the treatment of perennial asthma: a double-blind placebo-controlled study. J Allergy Clin Immunol. 1985 Jul;76(1):83-90.Products are for research use only. Not for human use.|