Product Name :
RWJ 50271
Description:
RWJ 50271 is an selective and orally active inhibitor of lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction with an IC50 of 5.0 μM (HL60 cells). RWJ 50271 inhibits LFA-1/ICAM-1-mediated cell adhesion.
CAS:
162112-37-0
Molecular Weight:
410.41
Formula:
C18H17F3N4O2S
Chemical Name:
N-(3-hydroxypropyl)-5-methyl-1-{4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}-1H-pyrazole-4-carboxamide
Smiles :
CC1=C(C=NN1C1=NC(=CS1)C1=CC(=CC=C1)C(F)(F)F)C(=O)NCCCO
InChiKey:
HOFGTYCLOKDAES-UHFFFAOYSA-N
InChi :
InChI=1S/C18H17F3N4O2S/c1-11-14(16(27)22-6-3-7-26)9-23-25(11)17-24-15(10-28-17)12-4-2-5-13(8-12)18(19,20)21/h2,4-5,8-10,26H,3,6-7H2,1H3,(H,22,27)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
RWJ 50271 is an selective and orally active inhibitor of lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction with an IC50 of 5.0 μM (HL60 cells). RWJ 50271 inhibits LFA-1/ICAM-1-mediated cell adhesion.|Product information|CAS Number: 162112-37-0|Molecular Weight: 410.41|Formula: C18H17F3N4O2S|Chemical Name: N-(3-hydroxypropyl)-5-methyl-1-{4-[3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl}-1H-pyrazole-4-carboxamide|Smiles: CC1=C(C=NN1C1=NC(=CS1)C1=CC(=CC=C1)C(F)(F)F)C(=O)NCCCO|InChiKey: HOFGTYCLOKDAES-UHFFFAOYSA-N|InChi: InChI=1S/C18H17F3N4O2S/c1-11-14(16(27)22-6-3-7-26)9-23-25(11)17-24-15(10-28-17)12-4-2-5-13(8-12)18(19,20)21/h2,4-5,8-10,26H,3,6-7H2,1H3,(H,22,27)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 250 mg/mL (609.{{Ecromeximab} MedChemExpress|{Ecromeximab} Epigenetics|{Ecromeximab} Protocol|{Ecromeximab} Data Sheet|{Ecromeximab} supplier} 15 mM; Need ultrasonic).{{Carvedilol} site|{Carvedilol} Autophagy|{Carvedilol} Technical Information|{Carvedilol} Data Sheet|{Carvedilol} supplier|{Carvedilol} Epigenetics} |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:23399686 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|RWJ 50271 inhibits adhesion of peripheral blood lymphocytes to plastic immobilized SICAM-1. RWJ 50271 inhibits both human and murine NK activity (IC50=5.0 μM) in an LFA-1/ICAM-1-dependent natural killer [NK] cytotoxicity assay. RWJ 50271 does not inhibit Mac-1/ICAM-1, E-selectidsialyl Lewis X or VLA-4/VCAM-1-mediated cell adhesion up to 20 μM concentrations. RWJ 50271 does not alter the LFA-1 expression levels on HL60 cells. RWJ 50271 inhibits adhesion of peripheral blood lymphocytes to plastic immobilized SICAM-1. RWJ 50271 does not exhibit any toxic activity up to 100 μM concentrations.|In Vivo:|RWJ 50271 (50 mg/kg; p.o.) is effective in animal model of inflammation.|Products are for research use only. Not for human use.|