Product Name :
kobe2602
Description:
Kobe2602, is analog of Kobe0065 , is is a potent and selective RAS inhibitor, which exhibit inhibitory activity toward H-Ras GTP-c-Raf-1 binding both in vivo and in vitro. Kobe2602 effectively inhibits both anchorage-dependent and -independent growth and induce apoptosis of H-ras(G12V)-transformed NIH 3T3 cells, which is accompanied by down-regulation of downstream molecules such as MEK/ERK, Akt, and RalA as well as an upstream molecule, Son of sevenless. Moreover, Kobe2602 exhibits antitumor activity on a xenograft of human colon carcinoma SW480 cells carrying the K-ras(G12V) gene by oral administration. Kobe2602 may serve as a scaffold for the development of Ras inhibitors with higher potency and specificity.
CAS:
454453-49-7
Molecular Weight:
419.31
Formula:
C14H9F4N5O4S
Chemical Name:
3-{[2,6-dinitro-4-(trifluoromethyl)phenyl]amino}-1-(4-fluorophenyl)thiourea
Smiles :
[O-][N+](=O)C1=CC(=CC(=C1NNC(=S)NC1=CC=C(F)C=C1)[N+]([O-])=O)C(F)(F)F
InChiKey:
NNPBSITXCGPXJC-UHFFFAOYSA-N
InChi :
InChI=1S/C14H9F4N5O4S/c15-8-1-3-9(4-2-8)19-13(28)21-20-12-10(22(24)25)5-7(14(16,17)18)6-11(12)23(26)27/h1-6,20H,(H2,19,21,28)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥360 days if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
Kobe2602, is analog of Kobe0065 , is is a potent and selective RAS inhibitor, which exhibit inhibitory activity toward H-Ras GTP-c-Raf-1 binding both in vivo and in vitro. Kobe2602 effectively inhibits both anchorage-dependent and -independent growth and induce apoptosis of H-ras(G12V)-transformed NIH 3T3 cells, which is accompanied by down-regulation of downstream molecules such as MEK/ERK, Akt, and RalA as well as an upstream molecule, Son of sevenless.{{Carvedilol} site|{Carvedilol} Autophagy|{Carvedilol} Biological Activity|{Carvedilol} In stock|{Carvedilol} manufacturer|{Carvedilol} Cancer} Moreover, Kobe2602 exhibits antitumor activity on a xenograft of human colon carcinoma SW480 cells carrying the K-ras(G12V) gene by oral administration.{{Pomalidomide} MedChemExpress|{Pomalidomide} Apoptosis|{Pomalidomide} Technical Information|{Pomalidomide} Description|{Pomalidomide} supplier|{Pomalidomide} Epigenetic Reader Domain} Kobe2602 may serve as a scaffold for the development of Ras inhibitors with higher potency and specificity.PMID:24914310 |Product information|CAS Number: 454453-49-7|Molecular Weight: 419.31|Formula: C14H9F4N5O4S|Chemical Name: 3-{[2,6-dinitro-4-(trifluoromethyl)phenyl]amino}-1-(4-fluorophenyl)thiourea|Smiles: [O-][N+](=O)C1=CC(=CC(=C1NNC(=S)NC1=CC=C(F)C=C1)[N+]([O-])=O)C(F)(F)F|InChiKey: NNPBSITXCGPXJC-UHFFFAOYSA-N|InChi: InChI=1S/C14H9F4N5O4S/c15-8-1-3-9(4-2-8)19-13(28)21-20-12-10(22(24)25)5-7(14(16,17)18)6-11(12)23(26)27/h1-6,20H,(H2,19,21,28)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|