Product Name :
AR-A 2
Description:
AR-A 2 is a selective 5-HT1B receptor antagonist, with high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki, 5 nM), and shows an EC50 of 4.5 nM for the guinea pig 5-HT1B receptor; AR-A 2 can be used in the research of depression and anxiety.
CAS:
220051-79-6
Molecular Weight:
448.60
Formula:
C27H36N4O2
Chemical Name:
N-[(2R)-5-methyl-8-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydronaphthalen-2-yl]-4-(morpholin-4-yl)benzamide
Smiles :
CN1CCN(CC1)C1=CC=C(C)C2CC[C@H](CC=21)NC(=O)C1C=CC(=CC=1)N1CCOCC1
InChiKey:
IHDRUIHIJWCTIY-JOCHJYFZSA-N
InChi :
InChI=1S/C27H36N4O2/c1-20-3-10-26(31-13-11-29(2)12-14-31)25-19-22(6-9-24(20)25)28-27(32)21-4-7-23(8-5-21)30-15-17-33-18-16-30/h3-5,7-8,10,22H,6,9,11-19H2,1-2H3,(H,28,32)/t22-/m1/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.{{Nicotinamide N-Methyltransferase/NNMT Protein, Human (His)} web|{Nicotinamide N-Methyltransferase/NNMT Protein, Human (His)} Purity & Documentation|{Nicotinamide N-Methyltransferase/NNMT Protein, Human (His)} Purity|{Nicotinamide N-Methyltransferase/NNMT Protein, Human (His)} supplier|{Nicotinamide N-Methyltransferase/NNMT Protein, Human (His)} Epigenetics}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
AR-A 2 is a selective 5-HT1B receptor antagonist, with high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptor (Ki, 5 nM), and shows an EC50 of 4.5 nM for the guinea pig 5-HT1B receptor; AR-A 2 can be used in the research of depression and anxiety.|Product information|CAS Number: 220051-79-6|Molecular Weight: 448.60|Formula: C27H36N4O2|Chemical Name: N-[(2R)-5-methyl-8-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydronaphthalen-2-yl]-4-(morpholin-4-yl)benzamide|Smiles: CN1CCN(CC1)C1=CC=C(C)C2CC[C@H](CC=21)NC(=O)C1C=CC(=CC=1)N1CCOCC1|InChiKey: IHDRUIHIJWCTIY-JOCHJYFZSA-N|InChi: InChI=1S/C27H36N4O2/c1-20-3-10-26(31-13-11-29(2)12-14-31)25-19-22(6-9-24(20)25)28-27(32)21-4-7-23(8-5-21)30-15-17-33-18-16-30/h3-5,7-8,10,22H,6,9,11-19H2,1-2H3,(H,28,32)/t22-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{SiRNA Negative Control} site|{SiRNA Negative Control} Epigenetics|{SiRNA Negative Control} Immunology/Inflammation|{SiRNA Negative Control} Biological Activity|{SiRNA Negative Control} In Vivo|{SiRNA Negative Control} supplier} |Shelf Life: ≥12 months if stored properly.PMID:24507727 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|AR-A 2 (AR-A000002) is a selective 5-HT1B receptor antagonist, with high affinity to guinea pig cortex 5HT1B/1D and recombinant guinea pig 5-HT1B receptors (Ki=0.24 and 0.47 nM) and with 10-fold lower affinity to guinea pig 5-HT1D receptors (Ki, 5 nM), and shows an EC50 of 4.5 nM for the guinea pig 5-HT1B receptor. AR-A 2 also binds to the rat cortical 5HT1B/1D receptor (Ki, 20 nM), rat cortex 5-HT2A receptor (Ki, 339 nM), rat hippocampus 5-HT1A receptor (Ki, 3070 nM). In addition, AR-A 2 also exhibits affinity for dopamine D2 (Ki, 330 nM) and α1-adrenoceptors (Ki, 490 nM).|Products are for research use only. Not for human use.|