Product Name :
PPOH
Description:
IC50: 9 μM for the formation of arachidonate 11,12 epoxides by CYP4A2 and CYP4A3 enzymes, respectively PPOH is an inhibitor of CYP epoxidase activity on arachadonic acid. Arachidonic acid can be converted by microsomal CYP450 enzymes to a variety of epoxides, ω-1 and ω-hydroxylated compounds through what is reported as the epoxidase pathway. In vitro: A previous study found that the inhibition of the epoxygenase pathway with PPOH was able to enhance the microvascular response to increasing renal perfusion pressure. In the presence of 50 mM PPOH, afferent arteriolar diameter decreased by 29% when pressure was increased from 80-160 mmHg. In contrast, the selective CYT-P450 hydroxylase inhibitor, N-methylsulphonyl-12,12-dibromododec-11-enamide could attenuate the vascular response to increasing renal perfusion pressure . In another study, it was shown that among the acetylenic compounds, both PPOH and N-methylsulfonyl-6-(2-propargyloxyphenyl)hexanamide were potent and selective inhibitors of microsomal epoxidation with IC50 values of 9 and 13 microM, respectively. Inhibition of microsomal activity by PPOH, but not DDMS, was time- and NADPH-dependent, which was a characteristic of a mechanism-based irreversible inhibitor . In vivo: Up to now, there is no animal in vivo data reported. Clinical trial: So far, no clinical study has been conducted.
CAS:
206052-01-9
Molecular Weight:
246.30
Formula:
C15H18O3
Chemical Name:
6-[2-(prop-2-yn-1-yloxy)phenyl]hexanoic acid
Smiles :
C#CCOC1=CC=CC=C1CCCCCC(O)=O
InChiKey:
CUNYTKVXYZYERK-UHFFFAOYSA-N
InChi :
InChI=1S/C15H18O3/c1-2-12-18-14-10-7-6-9-13(14)8-4-3-5-11-15(16)17/h1,6-7,9-10H,3-5,8,11-12H2,(H,16,17)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Amifostine} MedChemExpress|{Amifostine} Apoptosis|{Amifostine} Protocol|{Amifostine} In Vitro|{Amifostine} custom synthesis|{Amifostine} Autophagy}
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
IC50: 9 μM for the formation of arachidonate 11,12 epoxides by CYP4A2 and CYP4A3 enzymes, respectively PPOH is an inhibitor of CYP epoxidase activity on arachadonic acid. Arachidonic acid can be converted by microsomal CYP450 enzymes to a variety of epoxides, ω-1 and ω-hydroxylated compounds through what is reported as the epoxidase pathway.{{Calcitriol} web|{Calcitriol} VD/VDR|{Calcitriol} Protocol|{Calcitriol} Data Sheet|{Calcitriol} supplier|{Calcitriol} Epigenetics} In vitro: A previous study found that the inhibition of the epoxygenase pathway with PPOH was able to enhance the microvascular response to increasing renal perfusion pressure.PMID:23795974 In the presence of 50 mM PPOH, afferent arteriolar diameter decreased by 29% when pressure was increased from 80-160 mmHg. In contrast, the selective CYT-P450 hydroxylase inhibitor, N-methylsulphonyl-12,12-dibromododec-11-enamide could attenuate the vascular response to increasing renal perfusion pressure . In another study, it was shown that among the acetylenic compounds, both PPOH and N-methylsulfonyl-6-(2-propargyloxyphenyl)hexanamide were potent and selective inhibitors of microsomal epoxidation with IC50 values of 9 and 13 microM, respectively. Inhibition of microsomal activity by PPOH, but not DDMS, was time- and NADPH-dependent, which was a characteristic of a mechanism-based irreversible inhibitor . In vivo: Up to now, there is no animal in vivo data reported. Clinical trial: So far, no clinical study has been conducted.|Product information|CAS Number: 206052-01-9|Molecular Weight: 246.30|Formula: C15H18O3|Chemical Name: 6-[2-(prop-2-yn-1-yloxy)phenyl]hexanoic acid|Smiles: C#CCOC1=CC=CC=C1CCCCCC(O)=O|InChiKey: CUNYTKVXYZYERK-UHFFFAOYSA-N|InChi: InChI=1S/C15H18O3/c1-2-12-18-14-10-7-6-9-13(14)8-4-3-5-11-15(16)17/h1,6-7,9-10H,3-5,8,11-12H2,(H,16,17)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|