Product Name :
CSN5i-3
Description:
CSN5i-3 is a potent, selective and orally available inhibitor of CSN5/Jab1, and inhibits CSN-catalysed Cul1 deneddylation with an IC50 value of 5.8 nM.
CAS:
2375740-98-8
Molecular Weight:
505.56
Formula:
C28H29F2N5O2
Chemical Name:
3-(difluoromethyl)-N-{6-[(5S,6S)-6-hydroxy-5H,6H,7H,8H,9H-imidazo[1,5-a]azepin-5-yl]-[1,1′-biphenyl]-3-yl}-1-(propan-2-yl)-1H-pyrazole-5-carboxamide
Smiles :
CC(C)N1N=C(C=C1C(=O)NC1=CC(=C(C=C1)[C@H]1[C@@H](O)CCCC2=CN=CN21)C1C=CC=CC=1)C(F)F
InChiKey:
ANNKHJQLDMGQFM-UIOOFZCWSA-N
InChi :
InChI=1S/C28H29F2N5O2/c1-17(2)35-24(14-23(33-35)27(29)30)28(37)32-19-11-12-21(22(13-19)18-7-4-3-5-8-18)26-25(36)10-6-9-20-15-31-16-34(20)26/h3-5,7-8,11-17,25-27,36H,6,9-10H2,1-2H3,(H,32,37)/t25-,26-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
CSN5i-3 is a potent, selective and orally available inhibitor of CSN5/Jab1, and inhibits CSN-catalysed Cul1 deneddylation with an IC50 value of 5.{{AZD1390} medchemexpress|{AZD1390} ATM/ATR|{AZD1390} Activator|{AZD1390} Biological Activity|{AZD1390} Description|{AZD1390} manufacturer} 8 nM.|Product information|CAS Number: 2375740-98-8|Molecular Weight: 505.56|Formula: C28H29F2N5O2|Chemical Name: 3-(difluoromethyl)-N-{6-[(5S,6S)-6-hydroxy-5H,6H,7H,8H,9H-imidazo[1,5-a]azepin-5-yl]-[1,1′-biphenyl]-3-yl}-1-(propan-2-yl)-1H-pyrazole-5-carboxamide|Smiles: CC(C)N1N=C(C=C1C(=O)NC1=CC(=C(C=C1)[C@H]1[C@@H](O)CCCC2=CN=CN21)C1C=CC=CC=1)C(F)F|InChiKey: ANNKHJQLDMGQFM-UIOOFZCWSA-N|InChi: InChI=1S/C28H29F2N5O2/c1-17(2)35-24(14-23(33-35)27(29)30)28(37)32-19-11-12-21(22(13-19)18-7-4-3-5-8-18)26-25(36)10-6-9-20-15-31-16-34(20)26/h3-5,7-8,11-17,25-27,36H,6,9-10H2,1-2H3,(H,32,37)/t25-,26-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 100 mg/mL (197.80 mM).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Trospium} site|{Trospium} Neuronal Signaling|{Trospium} Protocol|{Trospium} Description|{Trospium} manufacturer|{Trospium} Autophagy} |Shelf Life: ≥12 months if stored properly.PMID:23671446 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|CSN5i-3 traps CRLs in the neddylated state, which leads to inactivation of a subset of CRLs by inducing degradation of their substrate recognition module.|In Vivo:|CSN5i-3 shows a good pharmacokinetic profile. CSN5i-3 inhibits growth of human xenograft. Treatment with CSN5i-3 triggers the formation of cleaved PARP and cleaved caspase 3 indicative of apoptosis induction.|Products are for research use only. Not for human use.|