Product Name :
Polycomb 2 polyclonal antibody
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Aliquots are stable for at least 12 months.
Description:
Polycomb 2 is a member of Drosophila Polycomb group gene family. The polycomb group (PcG) genes are essential for maintenance of proper expression patterns of developmental master regulators; changes in expression pf PcG proteins have been associated with cancer. Polycomb 2 is a part of the cellular memory system responsible for the inheritance of gene activity by progeny cells.{{23109-05-9} site|{23109-05-9} Technical Information|{23109-05-9} References|{23109-05-9} custom synthesis} It participates in maintaining the transcriptionally repressive state of genes.{{328968-36-1} MedChemExpress|{328968-36-1} Technical Information|{328968-36-1} Purity|{328968-36-1} supplier} Polycomb 2 is part of acomplex that acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A ‘Lys-119’, rendering chromatin heritably changed in its expressibility.PMID:29494101 Polycomb 2 is an E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I.
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| Alternative Name E3 SUMO-protein Ligase CBX4, Chromobox Protein Homolog 4, Pc2 | Application ELISA, IHC, WB | Formulation Liquid. In PBS containing 0.09% sodium azide. | Host Rabbit | Immunogen Synthetic peptide corresponding to a portion of N-terminal human Polycomb 2, conjugated to KLH. | Isotype IgG | Recommendation Dilutions/Conditions ELISA (1:1,000)Immunohistochemistry (1:50-1:100)Western Blot (1:100-1:500)Suggested dilutions/conditions may not be available for all applications.Optimal conditions must be determined individually for each application. | Species Reactivity Human, Mouse | UniProt ID O00257 | Unit of Measure (UM) µl