Product Name :
Rapamycin
Sequence:
Purity:
≥98% (HPLC)
Molecular Weight:
914.2
Solubility :
Soluble in chloroform, DMSO (25mg/ml), or 100% methanol.
Appearance:
Off-white or yellow solid.
Use/Stability :
As indicated on product label or CoA when stored as recommended. Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Description:
Immunosuppressant Antibiotic with immunosuppressant and anti-cancer propertiesCommonly used to study autophagy in a variety of cellsHighly cited Rapamycin is a macrocyclic-triene antibiotic with potent immunosuppressant activity.1456858-57-3 custom synthesis Rapamycin forms a complex with FKBP12 that binds to an effector, thus inhibiting IL-2 and other growth promoting lymphokines. The effectors were identified as FRAP (FKBP12 rapamycin-associated protein) and RAFT1 (rapamycin and KFBP12 target). Rapamycin/FKBP complex does not inhibit FRAP PI 4-kinase activity, but does inhibit FRAP autophosphorylation. Rapamycin induces inhibition of p70s6k, p33cdk2 and p34cdc2. Rapamycin selectively blocks signaling leading to the activation of p70/85 S6 kinase. Rapamycin complexed with FKBP12 binds to and inhibits the activity of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1).1849616-42-7 supplier Rapamycin can inhibit cell growth, enhance apoptosis, and activates autophagy in a variety of cell types.PMID:29999673
CAS :
53123-88-9
Solubility:
Soluble in chloroform, DMSO (25mg/ml), or 100% methanol.
Formula:
C51H79NO13
Additional Information :
| Alternative Name Sirolimus, AY-22,989, RAPA, Rapamune | Appearance Off-white or yellow solid. | CAS 53123-88-9 | Couple Target Immunophilin, mTOR | Couple Type Inhibitor, Ligand | Formula C51H79NO13 | MI 14: 8114 | MW 914.2 | Purity ≥98% (HPLC) | RTECS VE6250000 | Solubility Soluble in chloroform, DMSO (25mg/ml), or 100% methanol. | Source Isolated from Streptomyces hygroscopus | Technical Info / Product Notes Replacement for ADI-HPK-109. | Unit of Measure (UM) mg