Product Name :
MK-8745
Description:
MK-8745 is an aurora A kinase inhibitor with an IC50 of 0.6 nM.
CAS:
885325-71-3
Molecular Weight:
431.91
Formula:
C20H19ClFN5OS
Chemical Name:
6-[4-(3-chloro-2-fluorobenzoyl)piperazin-1-yl]methyl-N-(1,3-thiazol-2-yl)pyridin-2-amine
Smiles :
O=C(C1=CC=CC(Cl)=C1F)N1CCN(CC2C=CC=C(NC3=NC=CS3)N=2)CC1
InChiKey:
YCRFPWKUUNKNDN-UHFFFAOYSA-N
InChi :
InChI=1S/C20H19ClFN5OS/c21-16-5-2-4-15(18(16)22)19(28)27-10-8-26(9-11-27)13-14-3-1-6-17(24-14)25-20-23-7-12-29-20/h1-7,12H,8-11,13H2,(H,23,24,25)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
MK-8745 is an aurora A kinase inhibitor with an IC50 of 0.Irbesartan Purity & Documentation 6 nM.|Product information|CAS Number: 885325-71-3|Molecular Weight: 431.91|Formula: C20H19ClFN5OS|Chemical Name: 6-[4-(3-chloro-2-fluorobenzoyl)piperazin-1-yl]methyl-N-(1,3-thiazol-2-yl)pyridin-2-amine|Smiles: O=C(C1=CC=CC(Cl)=C1F)N1CCN(CC2C=CC=C(NC3=NC=CS3)N=2)CC1|InChiKey: YCRFPWKUUNKNDN-UHFFFAOYSA-N|InChi: InChI=1S/C20H19ClFN5OS/c21-16-5-2-4-15(18(16)22)19(28)27-10-8-26(9-11-27)13-14-3-1-6-17(24-14)25-20-23-7-12-29-20/h1-7,12H,8-11,13H2,(H,23,24,25)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 100 mg/mL (231.Simeprevir custom synthesis 53 mM).PMID:32956155 |Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|MK-8745 induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages. Exposure of p53 wild-type cells to MK-8745 results in the induction of p53 phosphorylation (ser15) and an increase in p53 protein expression. 1 μM of MK-8745 exposure for 24 h induces cell cycle arrest in all NHL cells, with variable degrees of G2/M arrest. Z138C cells are highly sensitive to MK-8745 (1 μ M) treatment and induces an approximate 5.5-fold increase in the G2/M phase cell population by 96 h. MK-8745 treatment inhibits phosphorylation of Aurora-A in Granta 519 and Z138C cells, while Akata and JVM2 has no effect. MK-8745 specifically inhibits Aurora-A specific function. MK-8745 treatment leads to apoptotic cell death.|Products are for research use only. Not for human use.|