These observations point out that the sumoylated neural RGSZ2 protein can bind to GPCR-activated GaGTP subunits but it shows no Gap exercise on them, relatively it delays the launch of GaiGDP subunits and impedes proper GTPase exercise at the Ga subunits
We analyzed no matter whether the mobile distribution of RGSZ2 is constant with its proposed role in regulating GPCR signaling. RGSZ2 mRNA was detected in the mouse mind and in…